We reviewed the clinical findings, histopathology, and clinical course in 21 cases of granuloma faciale. The disease can occur as macules, papules, plaques, or tumefactions, usually on the face; but the lesions may occur on other parts of the body. Children may be affected, but most cases occur in adults of middle age and older. The distinctive histopathology consists of a granulomatous infiltrate, tissue eosinophilia, and new capillary formation. The course of the disease is usually chronic with periods of slow progression alternating with intervals when the lesions remain static. There is no uniform response to any of the therapies now available, and spontaneous remission sometimes occurs.
PEDACE FJ, PERRY HO. Granuloma FacialeA Clinical and Histopathologic Review. Arch Dermatol. 1966;94(4):387-395. doi:10.1001/archderm.1966.01600280005001