Bloom's syndrome is a genodermatosis characterized by a telangiectatic erythema of the face beginning in infancy, sensitivity to sunlight, small stature, and a low birth weight after a full-term gestation. A structural chromosome abnormality and an increased incidence of leukemia are associated. A classical example of this syndrome is presented in a patient who also exhibited low yA and γM levels in the serum. Bloom's syndrome is compared with four other syndromes that have some similarity to it: Rothmund-Thomson syndrome, Cockayne's syndrome, ataxiatelangiectasia, and dyskeratosis congenita. These syndromes may be unrelated or may represent variants of the same underlying condition.
LANDAU JW, SASAKI MS, NEWCOMER VD, NORMAN A. Bloom's SyndromeThe Syndrome of Telangiectatic Erythema and Growth Retardation. Arch Dermatol. 1966;94(6):687–694. doi:10.1001/archderm.1966.01600300011003