The treatment of regional lymphomas by continuous infusion of antimetabolites through the arteries supplying the areas has been followed by enhanced antitumor effects locally. Complications have become fewer with familiarity of the techniques. Radiation therapy does not interfere, and the number and types of drugs explored, which are potentially effective by this route, are much larger than have been thus far explored. Casual use is strongly to be discouraged, yet there seems to be a real value to the procedure when carefully introduced.
FROMER JL, SULLIVAN RD. Continuous Arterial Infusion ChemotherapyFor Lymphoma and Other Cutaneous Malignant Tumors. Arch Dermatol. 1967;95(1):111-120. doi:10.1001/archderm.1967.01600310117028