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Article
February 1967

Cutaneous Cholesterol Ester Deposition in Tangier Disease

Author Affiliations

Bethesda, Md

From the Dermatology Branch, National Cancer Institute (Dr. Waldorf) and the Laboratory of Molecular Diseases, National Heart Institute (Drs. Levy and Fredrickson), National Institutes of Health, Bethesda, Md. Dr. Waldorf is now at the Department of Dermatology, New York University, School of Medicine, New York.

Arch Dermatol. 1967;95(2):161-165. doi:10.1001/archderm.1967.01600320017003
Abstract

Dermal deposition of cholesterol esters was found in cutaneous papules or clinically normal skin in four of the five known living patients with Tangier disease (familial α- or high-density lipoprotein deficiency). Five patients with Niemann-Pick disease and three normal patients studied in like manner exhibited no evidence of cutaneous cholesterol ester deposition.

These cutaneous findings will be useful in the diagnosis, follow-up, and study of this rare and interesting syndrome.

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