A patient with hepatolenticular degeneration (Wilson's disease) was treated with large doses of penicillamine and developed distinctive skin lesions. The lesions began as hemorrhagic vesicles and bullae in areas of pressure and healed with the formation of numerous inclusion cysts. It is possible that these skin lesions are due to the known action of penicillamine on collagen.
Katz R. Penicillamine-Induced Skin LesionsA Possible Example of Human Lathyrism. Arch Dermatol. 1967;95(2):196-198. doi:10.1001/archderm.1967.01600320052007