Forty-seven patients with rhinophyma were studied, five of whom had basal cell carcinoma of the nose. The microscopic changes of rhinophyma are characterized by epidermal epithelial hyperplasia and pilosebaceous gland hyperplasia, fibrosis, inflammation, and telangiectasia of the corium. It would appear that the incidence of basal cell carcinoma in rhinophyma is significantly greater than in the skin of normal noses. This indication of greater incidence among rhinophyma patients should be examined further by a study of the incidence of rhinophyma among basal cell carcinoma patients.
Acker DW, Helwig EB. Rhinophyma With Carcinoma. Arch Dermatol. 1967;95(3):250-254. doi:10.1001/archderm.1967.01600330008002