Two patients with epidermolysis bullosa hereditaria dystrophica treated with fluocinolone acetonide 0.2% cream and observed for eight months and five months, respectively, are presented. The results, though preliminary, are encouraging with respect to the rapid healing of individual bullous lesions so treated and also to the gradual but definite increase in tolerance of friction and trauma which has been observed in the treated areas. The local use of highly concentrated corticosteroid preparations is offered as a promising therapeutic modality in management of this discouraging and disabling chronic bullous disease for which so little effective therapy has been available.
Severin GL, Farber EM. The Management of Epidermolysis Bullosa in ChildrenEffective Topical Steroid Treatment. Arch Dermatol. 1967;95(3):302-309. doi:10.1001/archderm.1967.01600330060012