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Kyrle's Disease: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans in Siblings. Presented by Jack Weiner, MD.
The patients are a 6-year-old white boy and his 11-year-old sister who had normal-appearing skin at birth, but since early infancy, they have developed "wart-like" lesions on their skin at the sites of trauma. Each lesion appears to run a course. The initial hyperkeratotic papule eventually becomes inflamed, followed by involution and formation of a small, superficial scar. The usual sites involved are the dorsa of the hands, forearms, and knees. Their mother states that the lesions have always appeared following some type of injury. The boy recently developed small keratotic papules along three linear scratch marks on his right cheek. These have since disappeared without the usual residual scars. He also developed a violaceous, fusiform, keloid-like lesion on the left upper arm at the site of a scratch mark located alongside a second
Hambrick GW, Corson JK, Graham JH. PHILADELPHIA DERMATOLOGICAL SOCIETY. Arch Dermatol. 1967;95(3):329-334. doi:10.1001/archderm.1967.01600330087019