Betamethasone 17-valerate, a new corticosteroid synthesized expressly for topical use, was clinically evaluated in the treatment of various dermatoses in a two-part study. In the first part, a clinical-use study, betamethasone 17-valerate 0.1% cream produced excellent to good results in 139 (84%) of 166 patients. In the second part, a double-blind, bilateral, symmetrical paired comparison, betamethasone 17-valerate 0.05% ointment proved superior to the other corticosteroid in 37 (69%) of 54 patients, and the two were equally efficacious in 16 (29%). With the exception of two patients who developed local irritation, no gross evidence of systemic absorption or other adverse effects was noted.
Zimmerman EH. Betamethasone 17-ValerateA Custom-Made Topical Corticosteroid. Arch Dermatol. 1967;95(5):514-519. doi:10.1001/archderm.1967.01600350076015