A patient with chronic recurrent vesiculosquamous dermatitis of the palms and soles was found sensitive to methyl and propyl paraben in high dilution. The parabens are present in many therapeutic agents which come in contact with the skin, and sensitivity to them should be considered in patients with chronic dermatoses.
Schamberg IL. Allergic Contact Dermatitis to Methyl and Propyl Paraben. Arch Dermatol. 1967;95(6):626-628. doi:10.1001/archderm.1967.01600360072011