Investigations of the biology of melanin have increased in number and diversity during the last decade. Melanocytes, the cellular units of melanin formation, are easily identified by light and electron microscopy and can be grown in tissue culture. Studies of melanocytes have clinical significance because problems associated with melanocytic changes are constantly encountered in internal medicine, surgery, pediatrics, and neurology, as well as in dermatology.
Fitzpatrick TB, Miyamoto M, Ishikawa K. The Evolution of Concepts of Melanin Biology. Arch Dermatol. 1967;96(3):305-323. doi:10.1001/archderm.1967.01610030083015