The historical development of knowledge about mastocytosis (urticaria pigmentosa) in man is detailed. In most cases, the systemic implications of the mast cell overshadow the significance of cutaneous involvement.
Reports of recently described clinical varieties of mastocytosis are summarized.
A prototype of a patient with systemic mast cell disease is described.
Some practical considerations relating to the dermatopathologic study of this condition are presented.
Nickel WR. Clinical Spectrum of Mastocytosis. Arch Dermatol. 1967;96(4):364-366. doi:10.1001/archderm.1967.01610040014004