The term mastocytosis is preferred for spontaneous mast-cell disease in a variety of species, including man. Mastocytosis is most common in the dog and much less so in man, cat, and ox. Purely extracutaneous examples have been recorded in dog, cat, ox, and man.
Thorough review of canine mastocytosis indicates that it is an excellent model for its human counterpart. A possible viral cause for canine mastocytosis has recently been reported.
Transplantable murine mastocytomas probably are induced, rather than spontaneous, phenomena. Almost invariably their involvement is extracutaneous.
Orkin M. Mastocytosis in Animals. Arch Dermatol. 1967;96(4):381-385. doi:10.1001/archderm.1967.01610040031007