Two psoriatic patients are reported with hyperuricemia and gout who had an episode of acute gouty arthritis within 24 hours after the administration of methotrexate intravenously.
A patient with gout and psoriasis, in which treatment with methotrexate is contemplated should probably receive prophylactic colchicine to prevent the precipitation of gouty attacks.
Martin JH, Gordon M, Wallace R. Methotrexate in PsoriasisPrecipitation of Gout. Arch Dermatol. 1967;96(4):431-433. doi:10.1001/archderm.1967.01610040081015