A procedure for studying the cytology and morphology of the horny cells of the skin has been described. It is based upon removal of horny cells directly onto adhesive coated glass slides. By viewing the cells in their broad axes, many details may be seen which are concealed in traditional transverse sections. Optical systems and staining procedures are described to facilitate examination of normal and abnormal horny cells.
Goldschmidt H, Kligman AM. Exfoliative Cytology of Human Horny LayerMethods of Cell Removal and Microscopic Techniques. Arch Dermatol. 1967;96(5):572-576. doi:10.1001/archderm.1967.01610050094016