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November 1967


Arch Dermatol. 1967;96(5):588-597. doi:10.1001/archderm.1967.01610050110019

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Subcorneal Pustular Dermatosis. Presented by Drs. Raul Fleischmajer and Robert R. Koelsch.  A 47-year-old Negro woman, who was first hospitalized at Eagleville Hospital because of an abnormal chest x-ray film (January 1965), was transferred to Temple University Hospital where a diagnosis of sarcoidosis was made. She was readmitted to the hospital (July 1966) because of fever, lymphadenopathy, and hepatomegaly, and a liver biopsy revealed noncaseating granulomatous disease. However, sputum cultures were positive for tuberculosis and she was sent for treatment to Landis Hospital (October 1966). Two days prior to admission to Hahnemann (Jan 1, 1967), she developed an ulceration on the right medial malleolus that was treated orally with tetracycline. Almost simultaneously with the initiation of the antibiotic therapy, she developed a bullous eruption involving her abdomen, axillae, and groins that soon became confluent and quickly spread to thighs, upper chest, and shoulder areas. These bullae were noted to be

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