An immediate anaphylactic reaction to a single dose of penicillin occurred followed by a serum sickness-like reaction two weeks later without additional administration of penicillin or other drugs. This is the first report of both types of reaction to a single dose of penicillin, and it emphasizes the similarity between anaphylaxis and serum sickness.
Fellner MJ, Ball EH, Baer RL. "Double Reaction" to PenicillinAnaphylactic and Serum Sickness-Like Reactions Due to a Single Dose. Arch Dermatol. 1967;96(6):687-688. doi:10.1001/archderm.1967.01610060081013