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Article
January 1968

Untoward Response With Topical Fluorouracil

Author Affiliations

Miami, Fla

From the Department of Dermatology, University of Miami Medical School, Miami, Fla.

Arch Dermatol. 1968;97(1):14-22. doi:10.1001/archderm.1968.01610070020003
Abstract

Topical fluorouracil therapy is a major advance in the treatment of actinic keratoses. With extensive use, some untoward results can be anticipated. Contact dermatitis, both to the agent itself and to the vehicle in which it is employed, may occur. Acquired sensitivity occurred in a little more than 1% of the patients treated. Preexisting dermatoses may be accentuated by the inflammatory response which ensues from this procedure. Patients with chloasma and rosacea are most likely to encounter temporary accentuation of the underlying disorder. Pretreatment instructions regarding the expected reaction and weekly observation is recommended. Exposure to sunlight increases discomfort at the reactive stage but is not an absolute contraindication to treatment.

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