Normal skin and skin stripped of its stratum corneum from 40 individuals was tested for ability to sweat. Sweat rates were recorded with a modified Bullard sudorometer. Most subjects showed an increase in sweating with stratum corneum removal. We conclude that the so-called inactivity of the eccrine gland may be due not only to inability of its secretory function but to partial natural stratum corneum blockage. It is postulated that the proclivity to develop miliaria in heat and in diseased skin may be related to a propensity for this natural blocking of the stratum corneum.
Gordon BI, Maibach HI. On the Mechanism of the Inactive Eccrine Human Sweat Gland. Arch Dermatol. 1968;97(1):66-68. doi:10.1001/archderm.1968.01610070072010