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Article
January 1968

COMMENTS ON ANTINUCLEAR ANTIBODIES

Author Affiliations

Henry Ford Hospital Detroit

Arch Dermatol. 1968;97(1):99-100. doi:10.1001/archderm.1968.01610070105019
Abstract

To the Editor.—  Drs. Rowell and Beck in their article in the September 1967 issue of the Archives1 once again stated that the speckle-inducing antinuclear antibody is as frequent in systemic lupus erythematosus (SLE) as it is in scleroderma. We originally reported that "speckled" fluorescence was almost exclusively confined to scleroderma in our series2,3 even at the titration endpoint. We suggested that this difference might be attributable to Drs. Rowell and Beck including "speckle-like threads"2-4 which do occur with equal frequency in SLE and scleroderma, with true "speckles" in their classification of "speckled" fluorescence. Interestingly enough, in a letter to the editor of the Lancet by Drs. Beck and Hughes5 Fig C, depicting "speckled" fluorescence produced by the diluted serum of an SLE patient, appeared in fact to illustrate "speckle-like thready" fluorescence.Since our original reports, we have now tested 5,723 patients and have established that true

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