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February 1968

The Action Spectrum of Photocontact DermatitisCaused by Halogenated Salicylanilide and Related Compounds

Author Affiliations


From the departments of dermatology and pathology, Baylor University College of Medicine, Houston.

Arch Dermatol. 1968;97(2):130-136. doi:10.1001/archderm.1968.01610080034005

Nineteen patients with clinical features of a photocontact dermatitis by photopatch testing were proved to be sensitive to tetrachlorosalicylanilide, dibromsalan, metabromsalan, tribromsalan, hexachlorophene, bithionol, or triclocarban. The most common clinical findings were a lichenoid dermatitis of exposed skin of the hands, arms, face, and neck. Erythematous and eczematous reactions were also observed. Using a high intensity monochromator, action spectra delineated for tetrachlorosalicylanilide, dibromsalan, hexachlorophene, and bithionol revealed the effective wavelengths to be between 300 and 425 nanometer (nm). The shorter wavelengths were usually slightly more efficient in eliciting a threshold response. In one patient sensitive to triclocarban, no reactions were elicited with wavelengths longer than 360 nm.