A suppressive effect on early and moderately advanced lesions of mycosis fungoides was obtained by the use of fluocinolone acetonide cream (Synalar) in concentrations of 0.2% and 1.0% applied under plastic film occlusion. Less dependable, although at times favorable, results were noted with the 0.025% and 0.01% strengths. Clinical improvement was accompanied by involutionary histological changes. Evidence suggesting a direct influence of the steroid compound on the growth of the neoplastic cells has been presented.
Farber EM, Zackheim HS, McClintock RP, Cox AJ. Treatment of Mycosis FungoidesWith Various Strengths of Fluocinolone Acetonide Cream. Arch Dermatol. 1968;97(2):165-172. doi:10.1001/archderm.1968.01610080069013