Therapy with topically administered 5-fluorouracil under occlusion proved remarkably successful in resolving a large protuberant 8 × 10-cm lesion of Bowen's disease on the thigh of an 83-year-old man. Within 12 days, the lesion had sloughed and by one month the epidermis had returned to normal. Further trials with this agent under occlusion are warranted for the treatment of superficial malignancies.
Fulton JE, Carter DM, Hurley HJ. Treatment of Bowen's Disease With Topical 5-Fluorouracil Under Occlusion. Arch Dermatol. 1968;97(2):178-180. doi:10.1001/archderm.1968.01610080082016