Photocontact dermatitis to halogenated salicylanilides and related compounds was evaluated in 26 patients. The eruption was eczematous in nature and occurred primarily in 40-to 60-year-old men. Histologically, a dense perivascular round cell infiltrate was a consistent feature.
Positive photopatch tests to 3, 3′, 4′, 5 tetrachlorosalicylanilide (TCSA), the dibromosalicylanilides, and tribromosalicylanilide were most common. However, four patients showed positive reactions with hexachlorophene, three with carbanilides, and one with dichlorophene.
Graded exposure studies revealed minimal amounts of energy were necessary to produce the reactions.
Most patients improved following diagnosis. However, four remained photosensitive to a lesser degree for 3½ to 12 months and six were severe persistent reactors. Three of these latter individuals apparently had polymorphous light eruptions as well as photocontact dermatitis.
Epstein JH, Wuepper KD, Maibach HI. Photocontact Dermatitis to Halogenated Salicylanilides and Related CompoundsA Clinical and Histological Review of 26 Patients. Arch Dermatol. 1968;97(3):236-244. doi:10.1001/archderm.1968.01610090008002