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March 1968

Pseudolymphoma SyndromeA Sensitivity to Anticonvulsant Drugs

Author Affiliations

Tucson, Ariz

From the Associated Dermatologists, Professional Corporation, (Dr. Schreiber), and Tucson Clinic (Dr. McGregor), Tucson, Ariz.

Arch Dermatol. 1968;97(3):297-300. doi:10.1001/archderm.1968.01610090069010

A clinical and histopathologic picture of a lymphoma suddenly occurring in a patient on anticonvulsant drug therapy may represent a peculiar response of the individual's reticuloendothelial system to the drug. This case report exemplifies the phenomenon which we feel deserves the appelation of pseudolymphoma syndrome. Most anticonvulsant drugs can produce this picture with cross sensitizations, however, diphenylhydantoin (Dilantin) and mephenytoin (Mesantoin) are the commonest offenders.