A case report of an infant who died with sclerema neonatorum is presented. A detailed biochemical study revealed an unusually high ratio of saturated to unsaturated fatty acids (56.8:43.2) in the subcutaneous triglycerides of the sclerematous infant. Oleic (C18:1) acid was present in normal amounts. Several alternative hypotheses for explaining the sclerematous process are discussed.
Kellum RE, Ray TL, Brown GR. Sclerema NeonatorumReport of Case and Analysis of Subcutaneous and Epidermal-Dermal Lipids by Chromatographic Methods. Arch Dermatol. 1968;97(4):372-380. doi:10.1001/archderm.1968.01610100012002