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April 1968


Arch Dermatol. 1968;97(4):487-490. doi:10.1001/archderm.1968.01610100127019

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Mycosis Fungoides. Presented by Dr. Charles P. DeFeo. 

History.—  A 65-year-old white man has suffered from this condition for the past six years. He has had various infiltrated and noninfiltrated patches located across the body which in the past have responded to the usual small amounts of x-ray. Recently some of the lesions have become more persistent and have seemed to develop radio resistance.At this time we decided to apply a topical nitrogen mustard, 10 mg of mechlorethamine hydrochloride diluted with 20 cc of water applied to the patches twice a week. After the third application he developed a contact dermatitis caused by the medication. He also has utilized ultraviolet light with some good results in the past. Several basal cell epitheliomas have been removed from his face. Laboratory work-up in the past year has showed no significant findings.The biopsy of the infiltrated patches done in 1962 revealed

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