In a survey at the University of Minnesota Hospitals, we have not confirmed the conclusions from the similar study done by Dobson and associates at the University of Oregon regarding an association of internal cancer and palmar keratoses. Palmar keratoses were found in approximately similar frequency in our normal subjects and our patients with internal malignancy. We believe that the presence of palmar keratoses is not by itself an indication of need for a systemic search for malignancy.
Bean SF, Foxley EG, Fusaro RM. Palmar Keratoses and Internal MalignancyA Negative Study. Arch Dermatol. 1968;97(5):528-532. doi:10.1001/archderm.1968.01610110036005