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May 1968

Multicentric ReticulohistiocytosisReport of a Case With Histochemical Studies

Author Affiliations


From the Department of Dermatology, the Division of Pathology, and the Department of Rheumatic Disease, The Cleveland Clinic Foundation, Cleveland. Dr. Davies is now at the Medical Arts Clinic, Regina, Saskatchewan.

Arch Dermatol. 1968;97(5):543-547. doi:10.1001/archderm.1968.01610110051009

A case of multicentric reticulohistiocytosis is reported. It is a systemic condition but the cause is not known. Subjective and objective improvement occurred after the patient received a course of nitrogen mustard and ACTH followed by chlorambucil. Results of blood lipid studies were normal, and histochemical examination of the material in the giant cells showed a polysaccharide and a phospholipid present. There is no evidence of abnormal lipid metabolism, so rather than using the term ``lipoid dermato-arthritis,'' we prefer the term ``multicentric reticulohistiocytosis.''