A case of multicentric reticulohistiocytosis is reported. It is a systemic condition but the cause is not known. Subjective and objective improvement occurred after the patient received a course of nitrogen mustard and ACTH followed by chlorambucil. Results of blood lipid studies were normal, and histochemical examination of the material in the giant cells showed a polysaccharide and a phospholipid present. There is no evidence of abnormal lipid metabolism, so rather than using the term ``lipoid dermato-arthritis,'' we prefer the term ``multicentric reticulohistiocytosis.''
Davies NEJ, Roenigk HH, Hawk WA, O'Duffy JD. Multicentric ReticulohistiocytosisReport of a Case With Histochemical Studies. Arch Dermatol. 1968;97(5):543-547. doi:10.1001/archderm.1968.01610110051009