Three cases of generalized eruptive keratoacanthoma are reported, and the findings in these and in four cases from the literature are summarized. The seven cases represented both men and women, and ages ranged from 32 to 57 years. A discrete small papule of keratoacanthoma is the primary lesion, and larger lesions often occur. Lesions may be follicular and so closely set as to simulate keratoderma. Linear groups of lesions, masked facies with ectropion, mucosal lesions, and severe pruritus are special features. Histologically, all lesions, including those of mucous membranes, are keratoacanthomas. In this series, no associated diseases were noted. Methotrexate did not help two patients in whom it was tried, but local applications of vitamin A provided objective and subjective relief.
Winkelmann RK, Brown J. Generalized Eruptive KeratoacanthomaReport of Cases. Arch Dermatol. 1968;97(6):615-623. doi:10.1001/archderm.1968.01610120005001