When compared with normal epidermis, basal cell epitheliomas show increased activities of 6-phosphogluconate dehydrogenase, isocitric dehydrogenase, and phosphofructokinase. The activities of hexokinase, aldolase, pyruvic kinase, lactic dehydrogenase, and malic dehydrogenase are decreased in basal cell epithelioma as compared with normal epidermis. These latter findings are in contrast to prior studies with psoriatic epidermis in which the activities of all enzymes except phosphorylase were increased.
Halprin KM, Ohkawara A, Fukui K. Enzymatic Characteristics of Human Basal Cell Epithelioma. Arch Dermatol. 1968;98(1):80-84. doi:10.1001/archderm.1968.01610130086017