Amyloidosis Associated With Multiple Myeloma, Originally Suggestive of Lipoid Proteinosis. Presented by Dr. Vincent Cipollaro (Dr. Robert Binford).
The patient is a 63-year-old retired house painter who developed numbness of fingers eight years ago. Five years ago he began to notice a lumpy thickening of the fingers of both hands with progressive limitation of flexion of the fingers. During the past two years there has been rapid growth of nodules on the terminal digits and growth of hard, painless nodules on arms, neck, and thorax. A biopsy submitted to the Armed Forces Institute of Pathology in 1963 revealed the presence of a lipopolysaccharide complex in the nodules. Amyloid stains were negative. Hoarseness developed three to four years ago and progressive dysphagia for the past year. At the present time the patient can only drink liquids.
There is no family history of diabetes, skin disease, hoarseness, or consanguinity.
NEW YORK ACADEMY OF MEDICINEDepartment of Dermatology and Syphilology. Arch Dermatol. 1968;98(1):88-96. doi:10.1001/archderm.1968.01610130094022