Twenty patients suffering from contact dermatitis to potassium bichromate showed positive intradermal reactions with chromium chloride and with complexes prepared in vitro of heparin-chromium chloride and hyaluronic acid from human umbilical cord-chromium chloride. The reaction to chromium chloride was inhibited in all 20 patients tested with rabbit liver glycogen-chromium chloride complex prepared in vitro. The observation suggests that in chromium sensitivity occurring naturally in humans, hyaluronic acid might act as a carrier for chromium cation.
Twenty control individuals not suffering from potassium bichromate sensitivity did not react positively to chromium chloride nor to any of the above-mentioned complexes.
Cohen HA. Hyaluronic AcidA Specific Carrier of Chromium Sensitivity. Arch Dermatol. 1968;98(2):148-151. doi:10.1001/archderm.1968.01610140046010