During a 12-month period, we observed 17 young women who became allergic to nickel following earlobe piercing procedures. All of the women developed draining, eczematous, pierced lobes after wearing implanted earrings two to four weeks. Ten of them subsequently developed more widespread reactions. Fifteen of the 17 women had signs or symptoms of the atopic diathesis.
Watt TL, Baumann RR. Nickel Earlobe Dermatitis. Arch Dermatol. 1968;98(2):155-158. doi:10.1001/archderm.1968.01610140053012