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September 1968

Ichthyosiform DermatosesIII. Studies of Transepidermal Water Loss

Author Affiliations

Miami, Fla; New Brunswick, NJ

From the Department of Dermatology, University of Miami School of Medicine, Miami, Fla (Drs. Frost and Weinstein) and Johnson and Johnson Research, New Brunswick, New Jersey, (Drs. Bothwell and Wildnauer).

Arch Dermatol. 1968;98(3):230-233. doi:10.1001/archderm.1968.01610150016002

Transepidermal water loss (TWL) measurements in subjects having one of four distinct forms of ichthyosis were determined hygrometrically. The observed TWL was highest in epidermolytic hyperkeratosis but was significantly elevated above normal in all forms. The increased TWL rates through greatly thickened horny layers as compared to normal layers imply inefficient water barrier function of the stratum corneum in these disorders.