Further studies designed to clarify the isoenzymic forms of glycolytic enzymes within the human epidermis have revealed one protein (enzyme) with hexokinase activity, three with phosphoglucomutase activity, one with phosphohexose isomerase activity, five with aldolase activity, one with phosphoglycerate mutase activity, two with enolase activity, one with pyruvate kinase activity, and two with phosphorylase activity. The single form of hexokinase corresponds to type I of liver which is not insulin sensitive. The single form of pyruvate kinase corresponds to type III of liver which is not inducible by insulin. Both phosphorylase a and b which probably correspond to muscle type phosphorylase rather than liver are present in epidermis. In addition, a phosphorylase kinase capable of converting b to a can be demonstrated.
Halprin KM, Ohkawara A, Fukui K. Isoenzymes of the Human Epidermis. Arch Dermatol. 1968;98(3):299-309. doi:10.1001/archderm.1968.01610150085016