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Article
January 1969

Bullous Pemphigoid Associated With Systemic Lupus Erythematosus

Author Affiliations

Rochester, Minn; Buffalo, NY

From the Mayo Clinic and Mayo Foundation, Section of Dermatology (Dr. Muller), the Mayo Graduate School of Medicine, University of Minnesota, Rochester (Dr. Jordon), and the State University of New York at Buffalo, Department of Microbiology (Mr. Hale and Dr. Beutner).

Arch Dermatol. 1969;99(1):17-25. doi:10.1001/archderm.1969.01610190023004
Abstract

Three cases of bullous pemphigoid associated with systemic lupus erythematosus (SLE) are presented. Indirect immunofluorescent (IF) studies performed on sera from two of the patients revealed basement membrane zone antibodies characteristic of bullous pemphigoid and nuclear antibodies characteristic of SLE. Direct IF studies revealed in vivo bound γ-globulin localized to the basement membrane zone in skin biopsy specimens from two of these patients. Pathologic observations of a third patient with bullous pemphigoid who died of SLE are also presented. This association with SLE adds further support to a possible auto-immune disturbance being operative in bullous pemphigold.

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