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January 1969

ScleromyxedemaA Dramatic Response to Melphalan

Author Affiliations

New York

From the Department of Dermatology, College of Physicians and Surgeons, Columbia University and the Dermatology Service, Presbyterian Hospital; (Drs. Feldman, Shapiro, and Slatkin) and the Medical Service, Francis Delafield Hospital (Dr. Pick), New York.

Arch Dermatol. 1969;99(1):51-56. doi:10.1001/archderm.1969.01610190057010

A 65-year-old woman developed typical scleromyxedema, with the associated M-type abnormal serum protein and marrow plasmacytosis. Treatment with systemic melphalan resulted in a dramatic response. The dermatosis improved noticeably after one month and a biopsy taken after five months of therapy showed almost total restitution to normal. The response of the circulating paraprotein was slower, between four and seven months being required for an observable decrease to take place. The possible relationship between scleromyxedema and plasma cell myeloma is discussed.