[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.120.181. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1969

Staphylococcal Septicemia and Pustular PurpuraReport of Cases

Author Affiliations

Buffalo

From the Veterans Administration Hospital and Department of Medicine, State University of New York at Buffalo.

Arch Dermatol. 1969;99(1):82-85. doi:10.1001/archderm.1969.01610190088017
Abstract

Two patients with fatal staphylococcal septicemia and meningitis demonstrated pustular purpura upon initial examination. Thrombocytopenia was present in both, as was hematemesis. Although superficially resembling the purpura of meningococcemia or trauma, staphylococcal purpura was diagnosed when puncture of the skin lesions and gram stain of the expressed fluid revealed staphylococci. Appropriate antibiotic therapy thus preceded reports of positive blood cultures by many hours. One patient's serum hemolyzed rabbit red cells in vitro, and cerebral hemorrhage and hemorrhagic infarcts were prominent pathologic findings. These abnormalities are consistent with known effects of staphylococcal products, especially alpha toxin (hemolysin). Though only one of many causes of infective purpura, staphylococcal septicemia with purpura can be diagnosed by needle puncture and gram stain of suspicious lesions in acutely ill toxemic patients. Patients with this form of staphylococcal disease rarely recover.

×