A 2½-year-old child and his infant sibling developed febrile perianal cellulitis after the former had received a deltoid smallpox vaccination. Vaccinia virus was isolated from the perianal area in both cases, and histology of the lesions was compatible with cellulitis due to vaccinia virus. Staphlococcus aureus and group A streptococci were also recovered from the lesions.
Ruben FL, Papageorgiou SN, Lepow ML, Wolinsky E. Perianal Vaccinia With Associated Streptococcal and Staphylococcal Infection. Arch Dermatol. 1969;99(2):170-175. doi:10.1001/archderm.1969.01610200042007