The subject was a 14-year-old boy with Sutton's disease (leukoderma acquisitum centrifugum). Nine halo nevi were removed from his skin: seven from the trunk, one from the neck, and one from the deltoid area. Seven were examined with the light microscope, and all presented similar histologic findings. Two of the lesions were examined with the electron microscope, one in our laboratory and one at Harvard Medical School. In the depigmented epidermis of the halo we found active melanocytes. No melanocytes were found in the halo epidermis at Harvard. Lymphocytes and nevus cells were present in the nevus area of both specimens. There was evidence of cytotoxic effect in nevus cells and some melanocytes. A hypothetical sequence of immunologic events to account for the halo development is presented.
Stegmaier OC, Becker SW, Medenica M. Multiple Halo NeviHistopathological Findings in a 14-Year-Old Boy. Arch Dermatol. 1969;99(2):180-189. doi:10.1001/archderm.1969.01610200052009