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April 1969

Disseminated Superficial Actinic PorokeratosisGenetic Aspects

Author Affiliations


From the Section of Medical Genetics, University of Texas M. D. Anderson Hospital and Tumor Institute at Houston (Dr. Anderson), and the Department of Dermatology, Baylor University College of Medicine and Hermann Hospital (Dr. Chernosky), Houston.

Arch Dermatol. 1969;99(4):408-412. doi:10.1001/archderm.1969.01610220036006

A clinicogenetic study was made of ten famlies with disseminated superficial actinic porokeratosis (DSAP). Complete cutaneous examinations were conducted on 58 family members. Age significantly influenced the manifestation of DSAP; no cases were observed below 16 years of age, but after this age the frequency increased almost linearly with an increase in age. No differences were noted between males and females in affection rate, multiplicity of lesions, and age at first recognition. Genetic results indicated DSAP to be inherited as an autosomal dominant with reduced penetrance at young ages. No evidence of genetic linkage was found between the gene locus for DSAP and various blood group marker loci.