A case is reported of accentuation of ichthyotic scales within a localized area of cutaneous denervation in a patient with ichthyosis vulgaris. Determination of stratum corneum turnover time using a fluorescent dye (tetrachlorsalicylanilide) revealed a markedly increased scale adherence in the denervated area suggesting that cutaneous denervation increases epidermal turnover time.
Petrone GS. Accentuation of Ichthyosis Vulgaris in Denervated Skin. Arch Dermatol. 1969;100(1):42-45. doi:10.1001/archderm.1969.01610250048011