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To the Editor.—
The use of immunosuppressive drugs in pemphigus vulgaris has not, as far as we know, been published.We would like to report a case treated by a combination of steroids and azathioprine (Imuran) and, subsequently, by azathioprine only.
Report of a Case.—
A 66-year-old woman was hospitalized one year earlier because of extensive ulcerations of the mouth and scattered lesions on the head, shoulders, chest, and upper back. The blood pressure was 130/80. Biopsy from a skin lesion confirmed the diagnosis of pemphigus vulgaris.Prednisone therapy began with 100 mg daily. The mouth ulcerations healed; the skin lesions proved more resistant and by the end of three months cleared only partially. Attempts to lower the maintenance dose of prednisone to less than 30 mg a day failed.After several weeks' treatment the skin manifestations deteriorated. Because of the continued appearance of new lesions, increasing amounts of prednisone
Krakowski A, Covo J, Rozanski Z. PEMPHIGUS VULGARIS. Arch Dermatol. 1969;100(1):117. doi:10.1001/archderm.1969.01610250123031