Biopsies of skin lesions in cat-scratch disease have received relatively little attention. This report describes the histologic changes in four primary skin lesions, one conjunctival lesion, and one intradermal skin test.
The consistent changes observed were a central acellular zone of necrosis surrounded by histiocytes, giant cells, and a mantle of lymphocytes.
These findings are equivalent to changes reported in lymph nodes from cat-scratch disease, and biopsy of skin lesions is a recommended step to be included with other diagnostic studies for cat-scratch disease.
Johnson WT, Helwig EB. Cat-Scratch DiseaseHistopathologic Changes in the Skin. Arch Dermatol. 1969;100(2):148-154. doi:10.1001/archderm.1969.01610260024004