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August 1969

Sweat Gland Necrosis in Barbiturate Poisoning

Author Affiliations

Lexington, Ky

From the Department of Medicine, University of Kentucky Medical Center, Lexington, Ky.

Arch Dermatol. 1969;100(2):218-221. doi:10.1001/archderm.1969.01610260094017

Early diagnosis of barbiturate poisoning may be difficult in comatose patients. The presence of irregular erythematous cutaneous lesions and bullae may be of aid in this respect. In my patient, there was sweat gland necrosis. To my knowledge, this microscopic finding has not been previously reported. Necrosis of sweat glands may contribute to temperature variations seen in barbiturate poisoning.