Treatment of warts by inoculation with vaccinia virus was evaluated by treating with smallpox vaccine or saline alternatively. Two months after treatment with the saline placebo nearly half of the warts treated in 50 patients disappeared. Inoculation of vaccinia into warts caused some of them to disappear faster but the results in two months were not significantly different from the controls. Local and systemic side effects with the vaccine were too frequent to warrant further use of this form of treatment.
Israel RM. Treatment of Warts by Vaccination. Arch Dermatol. 1969;100(2):222-223. doi:10.1001/archderm.1969.01610260098018