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September 1969

KeratoacanthomaAssociation With Basal and Squamous Cell Carcinoma

Author Affiliations

Rochester, Minn

From the Section of Dermatology, Mayo Clinic and Mayo Foundation (Dr. Winkelmann), and the Mayo Graduate School of Medicine, University of Minnesota (Dr. Burge), Rochester, Minn.

Arch Dermatol. 1969;100(3):306-311. doi:10.1001/archderm.1969.01610270048011

A case is presented in which a keratoacanthoma, treated with methotrexate and tetracycline with subsequent resolution, developed a basal cell carcinoma in the keratoacanthoma scar. After surgical removal of the tumor and skin grafting, a squamous cell carcinoma that was invasive into the nasal cartilage appeared at the site.