A case of anaphylactic shock following topical administration of an ointment containing bacitracin and neomycin is described. Antibacitracin reagins were demonstrated in sera from a patient with atopic dermatitis and there is strong evidence that the anaphylactic reaction was due to hypersensitivity to this drug.
Roupe G, Strannegård Ö. Anaphylactic Shock Elicited by Topical Administration of Bacitracin. Arch Dermatol. 1969;100(4):450-452. doi:10.1001/archderm.1969.01610280068012