At the Mayo Clinic, four patients with porphyria cutanea tarda were treated with metabolic alkalinization by orally administered sodium bicarbonate for ten weeks to nine months. Clinically, blistering and ulceration that had occurred after sun exposure and trauma were reduced or completely alleviated. Under the experimental conditions outlined, the skin in the light-exposed areas in two of the patients became more resistant to controlled blistering by a suction apparatus. These observations of clinical activity and porphyrin excretion indicate that systemic alkalinization may be beneficial in the treatment of porphyria cutanea tarda.
Wiegand SE, Copeman PWM, Perry HO. Metabolic Alkalinization in Porphyria Cutanea Tarda. Arch Dermatol. 1969;100(5):544-549. doi:10.1001/archderm.1969.01610290028006